| MISSISSIPPI RIVER TRAIL | 48.6 Miles | |||||
| Cape Girardeau, MO to Charleston, MO | ||||||
| Total | ||||||
| Distance | Direction | To | Miles (S) | Miles (N) | ||
| 0 | Cape Girardeau (LRG) | 0 | ||||
| 3 | W | on | CR #K | I-55 (LRG) | 3 | 48.6 |
| 4.8 | W | on | CR #K | SR 25 | 7.8 | 45.6 |
| 6.9 | S | on | SR 25 | SR 77 | 14.7 | 40.8 |
| 2.9 | S | on | SR 77 | CR #A - Chaffee community | 17.6 | 33.9 |
| 0.8 | E | on | CR #A | Intersection | 18.4 | 31 |
| 0.1 | SE | on | CR #A | Intersection | 18.5 | 30.2 |
| 5.6 | S | on | CR #A | New Hamburg | 24.1 | 30.1 |
| 0.3 | E | on | CR #A | Intersection | 24.4 | 24.5 |
| 2 | S | on | CR #A | US 61 | 26.4 | 24.2 |
| 1.4 | S | on | US 61 | Benton (RG) | 27.8 | 22.2 |
| 0.6 | E | on | US 61 | SR 77 | 28.4 | 20.8 |
| 1.6 | SE | on | SR 77 | I-55 | 30 | 20.2 |
| 11.6 | SE | on | SR 77 | Town of Diehlstadt | 41.6 | 18.6 |
| 2.9 | E | on | SR 222 | CR #N | 44.5 | 7 |
| 4.1 | S | on | CR #N | Charleston | 48.6 | 4.1 |
| Town of Charleston (LRG) | 0 | |||||