| MISSISSIPPI RIVER TRAIL | 50.2 Miles | |||||
| Perryville, MO to Cape Girardeau, MO | ||||||
| Total | ||||||
| Distance | Direction | To | Miles (S) | Miles (N) | ||
| 0 | Perryville (LRG) | 0 | ||||
| 8.5 | S | on | US 61 | Longtown | 8.5 | 50.2 |
| East on CR #D to historic German villages of Frohna, Altenburg and Wittenberg | ||||||
| 5.6 | S | on | US 61 | Uniontown | 14.1 | 41.7 |
| 1.8 | S | on | US 61 | Old Appleton (G) | 15.9 | 36.1 |
| 11.8 | S | on | US 61 | SR 177 - Fruitland (G) | 27.7 | 34.3 |
| 6.5 | E | on | SR 177 | CR #V | 34.2 | 22.5 |
| 3.5 | S | on | CR #V | Intersection with CR #Y | 37.7 | 16 |
| 2.8 | E | on | CR #V | SR 177 - Trail of Tears SP (CG) | 40.5 | 12.5 |
| 2.9 | S | on | SR 177 | Egypt Mills community | 43.4 | 9.7 |
| 4.8 | S | on | SR 177 | Cape Girardeau (city limits) | 48.2 | 6.8 |
| 2 | S | on | SR 177 | Downtown Cape Girardeau | 50.2 | 2 |
| Cape Girardeau (LRG) - I-55 (3 miles) - many hotels | 0 | |||||